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KMID : 0525720160210020082
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Journal of Chitin and Chitosan
2016 Volume.21 No. 2 p.82 ~ p.88
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Immunomodulatory Effect of Sulfated Polysaccharides and Its Low Molecular Form Isolated from Enteromorpha prolifera in BALB/c Mice
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Kim Jin-Kyung
Park Ju-Hyung
Jang Eun-Hee
Utoomporn Surayot
You Sang-Guan
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Abstract
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Functional polysaccharides have increasingly garnered attention in health-care food and medicinal industries because of their various biological activities, such as immunomodulation, anti-cancer, anti-inflammation, and anti-oxidation. The immunomodulatory effects of sulfated polysaccharide (SP) from a green seaweed, Enteromorpha prolifera, and its derivative (SP-LMW) were investigated using BALB/c mice in this study. Mice were subjected to gavage once a day for 14 days with 5 or 20 mg/kg of SP, SP-LMW or vehicle. SP and SP-LMW did not considerably affect the body weight and relative liver weight after 14 days of administration, however, significant changes were observed in the ratio of immune cell populations and their biological functions, including cytokine production and NK cell cytotoxicity. The proportion of CD4+ T cells in the spleen substantially decreased in the SP-administered mice compared to the vehicle-treated mice. In addition, concanavalin-A treatment significantly reduced the proliferation of splenocytes in the SP-treated mice. On the other hand, the SP-LMW-treated mice considerably increased interferon-γ (INF-γ) and interleukin-2 (IL-2) production in concanavalin A-stimulated splenocytes. Collectively, these findings reveal that SP and SP-LMW may be potent immune-stimulators, modulating both innate and adaptive immune responses.
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KEYWORD
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Cytokines, Enteromorpha prolifera, Immunomodulatory effect, NK cell activity, Sulfated polysaccharides
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